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Source: http://aprsisce.wikidot.com/

APRSISCE/32 is an advanced Automatic Packet Reporting System (APRS) Client for Amateur Radio, written for Windows (x86 and x64) and Windows Mobile (CE). It will also run on Linux and Mac OS under WINE, as well as other virtual machines. It does *NOT* run on any Windows CE 5 or 6 GPS unit as of 2012/04/11.

APRSISCE/32 can be configured to run connected directly to the APRS-IS via an internet connection, as well as connected to the APRS-RF network via software modems such as UZ7HO Sound Modem, Dire Wolf or AGWPE, using a TNC, or one of the APRS capable Radios including the Kenwood TH-D72/TM-D710 and Yaesu FTM-350.